About Invokana® »

Invokana® (canagliflozin) is a drug prescribed to treat Type 2 diabetes. It belongs to a new class of drugs referred to as “Sodium Glucose co-transporter 2 (SGLT2) inhibitors.” Approved for sale by the FDA in 2013, Invokana® was the first of this new class to be sold in the United States. Invokana® and its related drugs, Invokamet and Invokamet XR are manufactured and sold by Johnson & Johnson and its subsidiary Janssen Pharmaceuticals. Other SGLT2 inhibitors - Farxiga and Xigduo XR (Astra Zeneca) and Jardiance and Glyxambi (Boehringer Ingelheim & Eli Lilly) – were subsequently approved for sale in the U.S. Each of these drugs comes in two forms: one as the sole drug and the other as a combination drug that includes the branded drug.

Invokana Amputations

Invokana® Injury Risks »

In 2017 the FDA issued a Drug Safety Communication confirming that patients taking Invokana®, Invokamet and Invokamet XR are at an increased risk of leg and foot amputations and that the manufacturers (Johnson & Johnson and its subsidiary Janssen Pharmaceuticals) must include a “Black Box Warning” on the drugs’ labeling.The Drug Safety Communication was issued after the FDA reviewed data from two different clinical trials – the CANVAS and CANVAS-R studies. These data demonstrated that diabetes patients treated with Invokana, Invokamet and Invokamet XR were twice as likely to require leg and foot amputations than those diabetes patients who were taking placebo (a non-drug). Also, in May 2015, the FDA issued a warning that use of Invokana could lead to diabetic ketoacidosis. Ketoacidosis occurs when cells are deprived of glucose, the body’s normal source of energy. Without glucose, the body breaks down fat for energy which produces ketones. High levels of ketones can poison the body leading to severe illness or death. In addition to ketoacidosis, Invokana use has been linked to kidney impairment, kidney failure, and most recently the risk of bone fractures due to decreased bone mineral density.

Case Evaluation

Case Evaluation »

We are currently accepting potential claims against the makers of Invokana® by users who have experienced serious adverse side effects including amputation of the legs, feet and/or toes, or ketoacidosis. If you or a loved one has been injured due to use of Invokana®, we would like to speak with you. Please call us toll-free at 1-888-276-3030 or send us your contact information and we will respond promptly.


Please fill in the form to request a FREE case evaluation from one of our attorneys if you or a loved one has suffered a lower limb amputation or developed ketoacidosis while taking Invokana®, Invokamet®, Invokamet® XR, Jardiance®, Farxiga®, or any other SGLT2 inhibitor.

Have you or someone you know suffered a lower limb amputation or developed ketoacidosis while taking Invokana®, Invokamet®, Invokamet® XR, Jardiance®, Farxiga®, or any other SGLT2 inhibitor? *

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